Biomarker generating
Single-transmembrane targets have parts inside, outside and within the membrane.
When an enzyme cuts the outside part, a piece of the target protein is released in the blood as a measurable biomarker.
Cutting Undruggable targets
Enzyme medicines can be designed to selectively trim and disable challenging targets
(such as Ion Channels, GPCRs, and Phosphatases).
Conditionally-activated Enzyme Medicine (CHAARM)
Sarana Bio had created a smart cutting tool (CHAARM) that can Cleave using a Highly Accurate Actuated Recognition Motif.